Indibulin
Cat. No.：YN270253
CAS No. ：204205-90-3
| 产品名称: | Indibulin |
| CAS No.: | 204205-90-3 |
| Chemical Name: | 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-1H-indole-3-acetamide |
| Synonyms: | ZIO 301; D 24851 |
| 分子量: | 389.83 |
| 分子式: | C₂₂H₁₆ClN₃O₂ |
| SMILES: | O=C(NC1=CC=NC=C1)C(C2=CN(CC3=CC=C(Cl)C=C3)C4=C2C=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Indibulin (ZIO 301)，一种口服有效的微管蛋白合成抑制剂，具有良好的抗癌活和极小的神经毒性。Indibulin 降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。 |
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Bacher, G., Nickel, B., Emig, P., et al.D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicityCancer Res.61(1),392-399(2001)
Wienecke, A., and Bacher, G.Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulinCancer Res.69(1),171-177(2009)
