NSC348884
Cat. No.：YN270271
CAS No. ：81624-55-7
| 产品名称: | NSC348884 |
| CAS No.: | 81624-55-7 |
| Chemical Name: | N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine |
| Synonyms: | N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺 |
| 分子量: | 636.79 |
| 分子式: | C₃₈H₄₀N₁₀ |
| SMILES: | CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC348884是核磷蛋白抑制剂, 破坏低聚物形成和诱导细胞凋亡，抑制不同癌细胞系增殖， IC50为1.7-4.0 μM。 |
| IC50和靶点: | |
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Qi, W., Shakalya, K., Stejskal, A., et al.NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cellsOncogene27(30),4210-4220(2008)
Zhang, J., Zhao, H.L., He, J.f., et al.Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2Zhongguo Yi Xue Ke Yuan Xue Bao34(1),58-61(2012)
