PD0166285 dihydrochloride
Cat. No.：YN270273
| 产品名称: | PD0166285 dihydrochloride |
| CAS No.: | 212391-63-4 |
| Chemical Name: | 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one, dihydrochloride |
| Synonyms: | PD-166285;PD 166285;PD 0166285 |
| 分子量: | 585.35 |
| 分子式: | C₂₆H₂₉Cl₄N₅O₂ |
| SMILES: | O=C1N(C)C2=NC(NC3=CC=C(OCCN(CC)CC)C=C3)=NC=C2C=C1C4=C(Cl)C=CC=C4Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD0166285 dihydrochloride是 P-gp 的一个底物，是WEE1抑制剂，也可微弱抑制Myt1，IC50值分别为 24 和 72 nM。PD0166285 dihydrochloride 对 Chk1 的 IC50值为3.433 μM。 |
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Panek, R.L., Lu, G.H., Klutchko, S.R., et al.In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitorJ. Pharmacol. Exp. Ther.283(3),1433-1444(1997)
Wang, Y., Li, J., Booher, R.N., et al.Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogatorCancer Res.61(22),8211-8217(2001)
Dimitroff, C.J., Klohs, W., Sharma, A., et al.Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: Implications for combination treatment with photodynamic therapyInvest. New Drugs17(2),121-135(1999)
