BML-277
Cat. No.：YN270275
| 产品名称: | BML-277 |
| CAS No.: | 516480-79-8 |
| Chemical Name: | 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide |
| Synonyms: | Chk2 Inhibitor II |
| 分子量: | 363.80 |
| 分子式: | C₂₀H₁₄ClN₃O₂ |
| SMILES: | ClC(C=C1)=CC=C1OC(C=C2)=CC=C2C3=NC4=CC(C(N)=O)=CC=C4N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BML-277 是一种选择性的检测点激酶 2 (Chk2) 抑制剂，IC50为 15 nM。 |
| IC50和靶点: | [{name:"Chk2:15 nM (IC50)"}] |
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| Solvent & Solubility: |
Arienti, K.L., Brunmark, A., Axe, F.U., et al.Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazolesJ. Med. Chem.48(6),1873-1885(2005)
Pereg, Y., Lam, S., Teunisse, A., et al.Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damageMol. Cell. Biol.26(18),6819-6831(2006)
