JIB-04
Cat. No.：YN270276
CAS No. ：199596-05-9
| 产品名称: | JIB-04 |
| CAS No.: | 199596-05-9 |
| Chemical Name: | phenyl-2-pyridinyl-methanone, (E,E)-2-(5-chloro-2-pyridinyl)hydrazone |
| Synonyms: | NSC 693627 |
| 分子量: | 308.76 |
| 分子式: | C₁₇H₁₃ClN₄ |
| SMILES: | ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JIB-04 是 Jumonji 组蛋白去甲基酶 (Jumonji histone demethylase) 广谱抑制剂，能抑制 JARID1A，JMJD2E，JMJD3，JMJD2A，JMJD2B，JMJD2C 和 JMJD2D 的活性，其IC50值分别为 230，340，855，445，435，1100 和 290 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wang, L., Chang, J., Varghese, D., et al.A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growthNat. Commun.4,2035(2013)
Easmon, J., Heinisch, G., Pürstinger, G., et al.Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activityJ. Med. Chem.40(26),4420-4425(1997)
