Domatinostat tosylate
Cat. No.：YN270331
CAS No. ：1186222-89-8
| 产品名称: | Domatinostat tosylate |
| CAS No.: | 1186222-89-8 |
| Chemical Name: | (2E)-N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide, 4-methylbenzenesulfonate |
| Synonyms: | 4SC-202 |
| 分子量: | 619.71 |
| 分子式: | C₃₀H₂₉N₅O₆S₂ |
| SMILES: | O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2.O=S(C5=CC=C(C)C=C5)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Domatinostat tosylate (4SC-202) 是一种 I 型HDAC抑制剂，能够抑制 HDAC1，HDAC2，和 HDAC3 的活性，IC50值分别为 1.20 μM，1.12 μM 和 0.57 μM；同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性。 |
| IC50和靶点: | [{name:"HDAC-3:0.57 μM (IC50)"},{name: "HDAC-2:1.12 μM (IC50)"},{name: "HDAC-1:1.2 μM (IC50)"},{name: "HDAC-11:9.7 μM (IC50)"},{name: "HDAC-5:11.3 μM (IC50)"},{name: "HDAC-10:21 μM (IC50)"},{name: "HDAC-9:50 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Maes, T., Carceller, E., Salas, J.A., et al.Advances in the development of histone lysine demethylase inhibitorsCurr. Opin. Pharmacol.23,52-60(2015)
Zhijun, H., Shusheng, W., Han, M., et al.Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cellsTumour Biol.37(8),10257-10267(2016)
