SBI-0206965
Cat. No.：YN270353
CAS No. ：1884220-36-3
| 产品名称: | SBI-0206965 |
| CAS No.: | 1884220-36-3 |
| Chemical Name: | 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-benzamide |
| Synonyms: | SBI0206965 |
| 分子量: | 489.32 |
| 分子式: | C₂₁H₂₁BrN₄O₅ |
| SMILES: | CNC(C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SBI-0206965 是一种强效, 选择性和细胞渗透性自噬激酶ULK1抑制剂, 抑制 ULK1 和 ULK2 激酶活性,IC50值分别为 108 nM 和 711 nM。 |
| IC50和靶点: | [{name:"ULK1:108 nM (IC50)"},{name: "ULK2:711 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Egan, D.F., Chun, M.G.H., Vamos, M., et al.Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 SubstratesMol. Cell59,285-297(2015)
