Gemcitabine
Cat. No.：YN270354
CAS No. ：95058-81-4
| 产品名称: | Gemcitabine |
| CAS No.: | 95058-81-4 |
| Chemical Name: | 2'-deoxy-2',2'-difluoro-cytidine |
| Synonyms: | 吉西他滨; LY 188011 |
| 分子量: | 263.20 |
| 分子式: | C₉H₁₁F₂N₃O₄ |
| SMILES: | O=C1N(C=CC(N)=N1)[C@H]2C(F)([C@@H]([C@H](O2)CO)O)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gemcitabine (LY 188011) 是一种嘧啶核苷类似物抗代谢药 (nucleoside antimetabolite/analog) 和抗肿瘤剂。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复，导致细胞自噬 (autophagy) 和凋亡 (apoptosis)。 |
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Slusarczyk, M., Lopez, M.H., Balzarini, J., et al.Application of ProTide technology to gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical developmentJ. Med. Chem.57(4),1531-1542(2014)
Bergman, A.M., Adema, A.D., Balzarini, J., et al.Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor modelsInvest. New Drugs29(3),456-466(2011)
Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al.New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridineMol. Cancer Ther.7(8),2415-2425(2008)
Merriman, R.L., Hertel, L.W., Schultz, R.M., et al.Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft modelsInvest. New. Drugs14(3),243-247(1996)
Obradovic, A., Ager, C., Turunen, M., et al.Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulatorsCancer Cell41(5),933-949(2023)
