Temozolomide
Cat. No.：YN270356
CAS No. ：85622-93-1
| 产品名称: | Temozolomide |
| CAS No.: | 85622-93-1 |
| Chemical Name: | 3,4-dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide |
| Synonyms: | 替莫唑胺; NSC 362856; CCRG 81045; TMZ |
| 分子量: | 194.15 |
| 分子式: | C₆H₆N₆O₂ |
| SMILES: | O=C(C1=C(N2C=N1)N=NN(C)C2=O)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Temozolomide (NSC 362856) 是一种可透过血脑屏障的口服活性的 DNA 烷基化 (DNA alkylating) 剂。Temozolomide 也是一种促自噬 (autophagy) 和促凋亡剂 (apoptosis)。Temozolomide 对以低水平的 O6-烷基鸟嘌呤 DNA 烷基转移酶 (OGAT) 和功能失配修复系统为特征的肿瘤细胞有效。Temozolomide 具有抗肿瘤和抗血管生成作用。 |
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Tsang, L.L.H., Quarterman, C.P., Gescher, A., et al.Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl-(triazen-1-yl)imidazole-4-carboxamideCancer Chemother. Pharmacol.27(5),342-346(1991)
Svec, R.L., Furiassi, L., Skibinski, C.G., et al.Tunable stability of imidazotetrazines leads to a potent compound for glioblastomaACS Chem. Biol.13(11),3206-3216(2018)
von Roemeling, C.A., Wang, Y., Qie, Y., et al.Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunityNat. Commun.11(1),1508(2020)
