(R)-CR8 trihydrochloride
Cat. No.：YN270366
CAS No. ：1786438-30-9
规格
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| 产品名称: | (R)-CR8 trihydrochloride |
| CAS No.: | 1786438-30-9 |
| Chemical Name: | |
| Synonyms: | CR8, (R)-Isomer trihydrochloride |
| 分子量: | 540.92 |
| 分子式: | C₂₄H₃₂Cl₃N₇O |
| SMILES: | CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO.Cl.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-CR8 (CR8) trihydrochloride 是 Roscovitine 的第二代类似物，是一种有效的CDK1/2/5/7/9抑制剂。(R)-CR8 trihydrochloride 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1 μM)、CDK9/cyclin T (0.18 μM) 和 CK1δ/ |
| IC50和靶点: | [{name:"CDK1/cyclinB1:0.09 μM (IC50)"},{name: "cdk2/cyclin A:0.072 μM (IC50)"},{name: "CDK2/cyclinE:0.041 μM (IC50)"},{name: "Cdk5/p25:0.11 μM (IC50)"},{name: "CDK7/cyclin H:1.1 μM (IC50)"},{name: "CDK9/Cyclin T:0.18 μM (IC50)"},{name: "CK1δ/ε:0.4 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
