Bendamustine hydrochloride
Cat. No.：YN270417
CAS No. ：3543-75-7
| 产品名称: | Bendamustine hydrochloride |
| CAS No.: | 3543-75-7 |
| Chemical Name: | 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid, monohydrochloride |
| Synonyms: | 盐酸苯达莫司汀; SDX-105 |
| 分子量: | 394.72 |
| 分子式: | C₁₆H₂₂Cl₃N₃O₂ |
| SMILES: | CN1C(C=CC(N(CCCl)CCCl)=C2)=C2N=C1CCCC(O)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bendamustine hydrochloride (SDX-105)，一种嘌呤类似物，是一种DNA交联剂。Bendamustine hydrochloride 可激活 DNA 损伤反应和细胞凋亡 (apoptosis)。Bendamustine hydrochloride 具有有效的烷基化，抗癌和抗代谢作用。 |
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Leoni, L.M., Bailey, B., Reifert, J., et al.Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agentsClin. Cancer Res.14(1),309-317(2008)
Konstantinov, S.M., Kostovski, A., Topashka-Ancheva, M., et al.Cytotoxic efficacy of bendamustine in human leukemia and breast cancer cell linesJ. Cancer Res. Clin. Oncol.128(5),271-278(2002)
Schwänen, C., Hecker, T., Hübinger, G., et al.In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemiaLeukemia16(10),2096-2105(2002)
Haskova, Z., Whitacre, M.N., Dede, K.A., et al.Combination therapy with ofatumumab and bendamustine in xenograft model of chronic lymphocytic leukaemiaBr. J. Haematol.156(3),402-404(2012)
