Mycophenolate Mofetil
Cat. No.：YN270419
CAS No. ：128794-94-5
规格
价格(RMB)
库存
| 产品名称: | Mycophenolate Mofetil |
| CAS No.: | 128794-94-5 |
| Chemical Name: | 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid, 2-(4-morpholinyl)ethyl ester |
| Synonyms: | 吗替麦考酚酯; RS 61443; TM-MMF |
| 分子量: | 433.49 |
| 分子式: | C₂₃H₃₁NO₇ |
| SMILES: | O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mycophenolate Mofetil 是非竞争性，选择性和可逆的肌苷一磷酸脱氢酶(IMPDH)抑制剂，免疫抑制剂，IC50分别为39 nM 和27 nM。 |
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Aygün, F., Efe, D., and Durgut, K.Comparison of MMF with prednisone in terms of rejection and duration of activity of transplant in rabbits that underwent retroperitoneal heterotopic heart transplantationCardiovasc. J. Afr.26(3),104-108(2015)
Dhande, I.S., Zhu, Y., Braun, M.C., et al.Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive ratsPhysiol. Genomics49(3),132-140(2017)
Taylor, E.B., and Ryan, M.J.Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune diseaseJ. Am. Heart Assoc.6(3),e005394(2017)
Fujiyama, N., Miura, M., Kato, S., et al.Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetilDrug Metab. Dispos.38(12),2210-2217(2010)
Räisänen-Sokolowski, A., Vuoristo, P., Myllärniemi, M., et al.Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allograftsTranspl. Immunol.3(4),342-351(1995)
