(E)-Flavokawain A
Cat. No.：YN270554
CAS No. ：37951-13-6
| 产品名称: | (E)-Flavokawain A |
| CAS No.: | 37951-13-6 |
| Chemical Name: | (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one |
| Synonyms: | 卡瓦胡椒素A |
| 分子量: | 314.33 |
| 分子式: | C₁₈H₁₈O₅ |
| SMILES: | O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(OC)C=C2.[E] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E)-Flavokawain A 是从卡瓦胡椒中提取的查尔酮，具有抗癌作用。(E)-Flavokawain A 通过介入 bax 蛋白依赖和线粒体依赖的凋亡通路，诱导膀胱癌细胞凋亡，抑制小鼠肿瘤生长。 |
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Pinner, K.D., Wales, C.T.K., Gristock, R.A., et al.Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytesPharm. Biol.54(9),1503-1512(2016)
Kwon, D.-J., Ju, S.M., Youn, G.S., et al.Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophagesFood Chem. Toxicol.58,479-486(2013)
Zi, X., and Simoneau, A.R.Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in miceCancer Res.65(8),3479-3486(2005)
