MIV-150
Cat. No.：YN250801
CAS No. ：231957-54-3
规格
价格(RMB)
库存
| 产品名称: | MIV-150 |
| CAS No.: | 231957-54-3 |
| Chemical Name: | N-(5-cyano-2-pyridinyl)-N-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]-urea |
| Synonyms: | PC 815 |
| 分子量: | 368.36 |
| 分子式: | C₁₉H₁₇FN₄O₃ |
| SMILES: | O=C(N[C@@H]1[C@H](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MIV-150 是NNTR的一个抑制剂，可以抑制 HIV-1 和 HIV-2 感染，其对 HIV-1/HIV-2 的EC50值为 <1 nM。 |
| IC50和靶点: | |
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Fernández-Romero, J.A., Thorn, M., Turville, S.G., et al.Carrageenan/MIV-150 (PC-815), a combination microbicideSex. Transm. Dis.34(1),9-14(2007)
Turville, S.G., Aravantinou, M., Miller, T., et al.Efficacy of Carraguardr-based microbicides in vivo despite variable in vitro activityPLoS One3(9),e3162(2008)
Singer, R., Derby, N., Rodriguez, A., et al.The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaquesJ. Virol.85(11),5504-5512(2011)
