Belinostat
Cat. No.：YN280018
CAS No. ：866323-14-0
规格
价格(RMB)
库存
| 产品名称: | Belinostat |
| CAS No.: | 866323-14-0 |
| Chemical Name: | (2E)-N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide |
| Synonyms: | 贝利司他; PXD101; PX105684 |
| 分子量: | 318.35 |
| 分子式: | C₁₅H₁₄N₂O₄S |
| SMILES: | O=S(NC1=CC=CC=C1)(C2=CC(/C=C/C(NO)=O)=CC=C2)=O.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Belinostat (PXD101; PX105684) 是一种有效的HDAC抑制剂，在 HeLa 细胞提取物中的IC50为 27 nM。 |
| IC50和靶点: | [{name:"HDAC6:82 nM (IC50)"},{name: "HDAC:27 nM (IC50, Hela cell)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Khan, N., Jeffers, M., Kumar, S., et al.Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitorsBiochem. J.409(2),581-589(2008)
Plumb, J.A., Finn, P.W., Williams, R.J., et al.Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101Mol. Cancer Ther.2(8),721-728(2003)
