Thiamet G
Cat. No.：YN280045
CAS No. ：1009816-48-1
| 产品名称: | Thiamet G |
| CAS No.: | 1009816-48-1 |
| Chemical Name: | 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol |
| Synonyms: | Thiamet-G |
| 分子量: | 248.30 |
| 分子式: | C₉H₁₆N₂O₄S |
| SMILES: | O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thiamet G 为有效，选择性的O-GlcNAcase抑制剂，其作用是从修饰的蛋白质中去除O-GlcNAc，抑制人 OGA 的Ki值为 20 nM。 |
| IC50和靶点: | |
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Liu, F., Iqbal, K., Grundke-Iqbal, I., et al.O-GlnNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's diseaseProc. Natl. Acad. Sci. USA101(29),10804-10809(2004)
Yuzwa, S.A., Macauley, M.S., Heinonen, J.E., et al.A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivoNat. Chem. Biol.4(8),483-490(2008)
