MK-5108
Cat. No.：YN280055
CAS No. ：1010085-13-8
| 产品名称: | MK-5108 |
| CAS No.: | 1010085-13-8 |
| Chemical Name: | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid |
| Synonyms: | VX-689 |
| 分子量: | 461.94 |
| 分子式: | C₂₂H₂₁ClFN₃O₃S |
| SMILES: | FC(C(Cl)=CC=C1)=C1O[C@H](CC2)CC[C@@]2(C(O)=O)CC3=CC=CC(NC4=NC=CS4)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-5108是高效和特异性的极光激酶A抑制剂，IC50值为0.064 nM。 |
| IC50和靶点: | [{name:"Aurora A:64 pM (IC50)"}] |
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| Solvent & Solubility: |
Harrington, E.A., Bebbington, D., Moore, J., et al.VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivoNat. Med.10(3),262-267(2004)
Shimmoura, T., Hasako, S., Nakatsuru, Y., et al.MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxelMol. Cancer Ther.9(1),157-166(2010)
