ABT-751
Cat. No.：YN280056
CAS No. ：141430-65-1
| 产品名称: | ABT-751 |
| CAS No.: | 141430-65-1 |
| Chemical Name: | N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-benzenesulfonamide |
| Synonyms: | E7010 |
| 分子量: | 371.41 |
| 分子式: | C₁₈H₁₇N₃O₄S |
| SMILES: | COC1=CC=C(C=C1)S(=O)(NC2=C(N=CC=C2)NC3=CC=C(C=C3)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABT-751(E 7010)是新型的生物相容性的微管蛋白结合剂和抗有丝分裂磺胺类化合物，对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。 |
| IC50和靶点: | |
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Yoshimatsu, K., Yamaguchi, A., Yoshino, H., et al.Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulinCancer Res.57(15),3208-3213(1997)
Morton, C.L., Favours, E.G., Mercer, K.S., et al.Evaluation of ABT-751 against childhood cancer models in vivoInvest. New. Drugs25(4),285-295(2007)
Luo, Y., Hradil, V.P., Frost, D.J., et al.ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculatureAnticancer Drugs20(6),483-492(2009)
