Zebularine
Cat. No.：YN280057
CAS No. ：3690-10-6
| 产品名称: | Zebularine |
| CAS No.: | 3690-10-6 |
| Chemical Name: | 1H-β-D-ribofuranosyl-2-pyrimidinone |
| Synonyms: | NSC309132; 4-Deoxyuridine |
| 分子量: | 228.20 |
| 分子式: | C₉H₁₂N₂O₅ |
| SMILES: | O=C1N=CC=CN1[C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zebularine (NSC309132; 4-Deoxyuridine)是DNA甲基转移酶抑制剂；也可抑制胞苷脱氨酶，Ki值为0.95 μM。 |
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Zhou, L., Cheng, X., Connolly, B.A., et al.Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferasesJ. Mol. Biol.321(4),591-599(2002)
Champion, C., Guianvarc'h, D., Sénamaud-Beaufort, C., et al.Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularinePLoS One5(8),e12388(2010)
Stresemann, C., Brueckner, B., Musch, T., et al.Functional diversity of DNA methyltransferase inhibitors in human cancer cell linesCancer Res.66(5),2794-2800(2006)
Yoo, C.B., Chuang, J.C., Byun, H.M., et al.Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in miceCancer Prev. Res.1(4),233-240(2008)
