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Zoledronic acid monohydrate

Cat. No.:YN280068

  • CAS No. :165800-06-6

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Zoledronic acid monohydrate
      CAS No.: 165800-06-6
      Chemical Name: P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid, monohydrate
      Synonyms:唑来膦酸一水合物; Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate
      分子量:290.10
      分子式:C₅H₁₂N₂O₈P₂
      SMILES:OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Zoledronic acid monohydrate 是第三代含氮二磷酸盐,能够抑制破骨细胞介导的骨吸收,同时具有抗肿瘤的活性。
      IC50和靶点:
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    • Li, E.C., and David, L.E.Zoledronic acid: A new parenteral bisphosphonateClin. Ther.25(11),2669-2708(2003)

      Nancollas, G.H., Tang, R., Phipps, R.J., et al.Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatiteBone38(5),617-627(2006)

      Räkel, A., Boucher, A., and Ste-Marie, L.G.Role of zoledronic acid in the prevention and treatment of osteoporosisClin. Interv. Aging6,89-99(2011)

      El-Amm, J., Freeman, A., Patel, N., et al.Bone-targeted therapies in metastatic castration-resistant prostate cancer: Evolving paradigmsProstate Cancer2013,1-10(2013)

      Major, P.The use of zoledronic acid, a novel, highly potent bisphosphonate, for the treatment of hypercalcemia of malignancyOncologist7(6),481-491(2002)

      Michou, L., and Brown, J.P.Emerging strategies and therapies for treatment of Paget's disease of boneDrug Des. Devel. Ther.5,225-239(2011)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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