GSK4112
Cat. No.：YN280072
CAS No. ：1216744-19-2
| 产品名称: | GSK4112 |
| CAS No.: | 1216744-19-2 |
| Chemical Name: | N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-glycine, 1,1-dimethylethyl ester |
| Synonyms: | SR6452 |
| 分子量: | 396.89 |
| 分子式: | C₁₈H₂₁ClN₂O₄S |
| SMILES: | ClC1=CC=C(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK4112是一种Rev-erbα激动剂, EC50为0.4 μM, GSK4112是小分子化学探针, 用于核血红素受体REV-erbα的细胞生物学研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lin, J.D.Minireview: The PGC-1 coactivator networks: Chromatin-remodeling and mitochodrial energy metabolismMol. Endocrinol.23(1),2-10(2009)
Lin, J.D., Liu, C., and Li, S.Integration of energy metabolism and the mammalian clockCell Cycle7(4),453-457(2008)
Grant, D., Yin, L., Collins, J.L., et al.GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbαACS Chem. Biol.5(10),925-932(2010)
Kojetin, D., Wang, Y., Kameneck, T.M., et al.Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERBACS Chem. Biol.6(2),131-134(2011)
Chen, H., Chu, G., Zhao, L., et al.Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112Biochem. Biophys. Res. Commun.420(2),374-379(2012)
