4E1RCat
Cat. No.:YN280073
CAS No. :328998-25-0
产品名称: | 4E1RCat |
CAS No.: | 328998-25-0 |
Chemical Name: | 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-benzoic acid |
Synonyms: | Benzoic acid,4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;(E)-4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic;(E)-4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2- |
分子量: | 478.45 |
分子式: | C₂₈H₁₈N₂O₆ |
SMILES: | O=C(O)C1=CC=C(N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4)=O)C=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | 4E1RCat 是一种 cap 依赖性翻译抑制剂,能够抑制eIF4E:eIF4GI相互作用,IC50值约为 4 μM。 |
IC50和靶点: | |
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Solvent & Solubility: |
Cencic, R., Hall, D.R., Robert, F., et al.Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4FProc. Natl. Acad. Sci. USA108(3),1046-1051(2011)