Reversine
Cat. No.：YN280077
CAS No. ：656820-32-5
| 产品名称: | Reversine |
| CAS No.: | 656820-32-5 |
| Chemical Name: | N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine |
| Synonyms: | 逆转素 |
| 分子量: | 393.49 |
| 分子式: | C₂₁H₂₇N₇O |
| SMILES: | C1(NC2=CC=C(N3CCOCC3)C=C2)=NC(NC4CCCCC4)=C5C(NC=N5)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Reversine 是一种ATP-竞争性的Aurora kinase抑制剂，作用于Aurora A，Aurora B和Aurora C，IC50分别为 400，500 和 400 nM。 |
| IC50和靶点: | [{name:"Aurora A:400 nM (IC50)"},{name: "Aurora B:500 nM (IC50)"},{name: "Aurora C:400 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chen, S., Zhang, Q., Wu, X., et al.Dedifferentiation of lineage-committed cells by a small moleculeJ. Am. Chem. Soc.126(2),410-411(2004)
D'Alise, A.M., Amabile, G., Iovino, M., et al.Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cellsMol. Cancer Ther.7(5),1140-1149(2008)
Perreira, M., Jiang, J.K., Klutz, A.M., et al."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonistsJ. Med. Chem.48(15),4910-4918(2005)
Santaguida, S., Tighe, A., D'Alise, A.M., et al.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineJ. Cell. Biol.190(1),73-87(2010)
Lu, C.-H., Liu, Y.-W., Hua, S.-C., et al.Autophagy induction of reversine on human follicular thyroid cancer cellsBiomed. Pharmacother.66(8),642-647(2012)
