Rabusertib
Cat. No.：YN280078
CAS No. ：911222-45-2
| 产品名称: | Rabusertib |
| CAS No.: | 911222-45-2 |
| Chemical Name: | N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-urea |
| Synonyms: | LY2603618; IC-83 |
| 分子量: | 436.30 |
| 分子式: | C₁₈H₂₂BrN₅O₃ |
| SMILES: | BrC(C=C1NC(NC2=NC=C(N=C2)C)=O)=C(C=C1OC[C@H]3OCCNC3)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rabusertib (LY2603618) 是一种有效的选择性的Chk1抑制剂，IC50为 7 nM。 |
| IC50和靶点: | [{name:"Chk1:7 nM (IC50)"},{name: "Chk2:12000 nM (IC50)"},{name: "PDK1:893 nM (IC50)"},{name: "CAMK2:1550 nM (IC50)"},{name: "VEGFR3:2128 nM (IC50)"},{name: "MET:2200 nM (IC50)"},{name: "JNK1:4930 nM (IC50)"},{name: "RSK2:5700 nM (IC50)"},{name: "NTRK1:12000 nM (IC50)"}] |
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King, C., Diaz, H., Barnard, D., et al.Characterization and preclinical development of LY2603618: A selective and potent Chk1 inhibitorInvest New Drugs32(2),213-226(2014)
Wang, F.-Z., Fei, H.-r., Cui, Y.-J., et al.The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cellsApoptosis19(9),1389-1398(2014)
Barnard, D., Diaz, H.B., Burke, T., et al.LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor modelsInvest New Drugs34(1),49-60(2016)
