Elaiophylin
Cat. No.：YN280079
CAS No. ：37318-06-2
| 产品名称: | Elaiophylin |
| CAS No.: | 37318-06-2 |
| Chemical Name: | 5001B; Antibiotic 5001B; Antibiotic 56-62; Antibiotic A 164AB; Azalomycin B; Efomycin E; Efomycine E; Gopalamicin; [7S-[3E,5E,7R*,8R*[1R*,2S*,3R*(2S*,4S*,5S*,6S*)],11E,13E,15R*,16R*[1R*,2S*,3R*(2S*,4S*,5S*,6S*)]]]-8,16-Bis[3-[4-[(2,6-dideoxy-α-L-lyxo-hexo |
| Synonyms: | Azalomycin B; Gopalamicin; Efomycin E |
| 分子量: | 1025.27 |
| 分子式: | C₅₄H₈₈O₁₈ |
| SMILES: | C[C@H]1[C@@H](O)[C@@H](O)C[C@H](O[C@@H]2C[C@@]([C@H]([C@H](O)[C@H](C)[C@](OC(/C=C/C=C/[C@H](C)[C@]([C@@H](C)[C@@H](O)[C@@H]([C@]3(O)O[C@H](C)[C@@H](CC)[C@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)C3)C)([H])OC5=O)=O)([H])[C@H](/C=C/C=C/5)C)C)(O)O[C@H](C)[C@H]2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) 是一种自噬 (autophagy) 抑制剂，在卵巢癌细胞中作为单一药剂发挥抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Fiedler, H.P., Wörner, W., Zähner, H., et al.Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceonigerJ. Antibiot. (Tokyo)34(9),1107-1118(1981)
Fang, A., Wong, G.K., and Demain, A.L.Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericinJ. Antibiot. (Tokyo)53(2),158-162(2000)
Otoguro, K., Iwatsuki, M., Ishiyama, A., et al.In vitro and in vivo antiprotozoal activities of bispolides and their derivativesJ. Antibiot. (Tokyo)63(5),275-277(2010)
Grigoriev, P.A., Schlegel, R., and Gräfe, U.Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranesBioelectrochemistry54(1),11-15(2001)
