Cabergoline
Cat. No.：YN280080
CAS No. ：81409-90-7
| 产品名称: | Cabergoline |
| CAS No.: | 81409-90-7 |
| Chemical Name: | N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-ergoline-8β-carboxamide |
| Synonyms: | 卡麦角林; FCE-21336 |
| 分子量: | 451.60 |
| 分子式: | C₂₆H₃₇N₅O₂ |
| SMILES: | C=CCN1[C@](C2C[C@@H](C(N(CCCN(C)C)C(NCC)=O)=O)C1)([H])CC3=CNC4=CC=CC2=C43 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cabergoline 是一种麦角衍生的多巴胺 D2亚类受体激动剂，高亲和力作用于D2，D3和5-HT2B受体，Ki分别为 0.7，1.5 和 1.2。 |
| IC50和靶点: | |
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Miyagi, M., Itoh, F., Taya, F., et al.Dopamine receptor affinities in vitro and stereotypic activities in vivo of cabergoline in ratsBiol. Pharm. Bull.19(9),1210-1213(1996)
Eguchi, K., Kawamoto, K., Uozumi, T., et al.Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors: In vitro culture studiesEndocr. J.42(3),413-420(1995)
Lin, S.J., Leng, Z.G., Guo, Y.H., et al.Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergolineOncotarget6(36),39329-39341(2015)
Grondin, R., Goulet, M.T., Di Paolo, T., et al.Cabergoline, a long-acting dopamine D2-like receptor agonist, produces a sustained antiparkinsonian effect with transient dyskinesias in parkinsonian drug-naive primatesBrain Res.735(2),298-306(1996)
