UNC1999
Cat. No.：YN280085
CAS No. ：1431612-23-5
| 产品名称: | UNC1999 |
| CAS No.: | 1431612-23-5 |
| Chemical Name: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-1H-indazole-4-carboxamide |
| Synonyms: | UNC1999; UNC 1999 |
| 分子量: | 569.74 |
| 分子式: | C₃₃H₄₃N₇O₂ |
| SMILES: | O=C1C(CNC(C2=C(C=NN3C(C)C)C3=CC(C4=CN=C(N5CCN(C(C)C)CC5)C=C4)=C2)=O)=C(CCC)C=C(C)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC1999 是一种有效，选择性和SAM-竞争性的EZH2和EZH1抑制剂，IC50分别为 <10 nM 和 45 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
Konze, K.D., Ma, A., Li, F., et al.An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1ACS Chem. Biol.8(6),1324-1334(2013)
