Gemcitabine hydrochloride
Cat. No.：YN280110
CAS No. ：122111-03-9
| 产品名称: | Gemcitabine hydrochloride |
| CAS No.: | 122111-03-9 |
| Chemical Name: | 2'-deoxy-2',2'-difluoro-cytidine, monohydrochloride |
| Synonyms: | 盐酸吉西他滨; LY 188011 hydrochloride |
| 分子量: | 299.66 |
| 分子式: | C₉H₁₂ClF₂N₃O₄ |
| SMILES: | OC[C@@H]1[C@H](C(F)(F)[C@H](N2C(N=C(C=C2)N)=O)O1)O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gemcitabine Hydrochloride (LY 188011 hydrochloride) 是一种DNA合成抑制剂，抑制 BxPC-3，Mia Paca-2，PANC-1，PL-45 和 AsPC-1细胞生长的IC50分别为 37.6, 42.9, 92.7, 89.3 和 131.4 nM。 |
| IC50和靶点: | |
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Slusarczyk, M., Lopez, M.H., Balzarini, J., et al.Application of ProTide technology to gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical developmentJ. Med. Chem.57(4),1531-1542(2014)
Bergman, A.M., Adema, A.D., Balzarini, J., et al.Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor modelsInvest. New Drugs29(3),456-466(2011)
Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al.New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridineMol. Cancer Ther.7(8),2415-2425(2008)
Merriman, R.L., Hertel, L.W., Schultz, R.M., et al.Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft modelsInvest. New. Drugs14(3),243-247(1996)
Obradovic, A., Ager, C., Turunen, M., et al.Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulatorsCancer Cell41(5),933-949(2023)
