Oxidopamine hydrobromide
Cat. No.：YN280119
CAS No. ：636-00-0
| 产品名称: | Oxidopamine hydrobromide |
| CAS No.: | 636-00-0 |
| Chemical Name: | 5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide |
| Synonyms: | 6-羟基多巴胺氢溴酸盐; 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide |
| 分子量: | 250.09 |
| 分子式: | C₈H₁₂BrNO₃ |
| SMILES: | OC1=CC(CCN)=C(O)C=C1O.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxidopamine hydrobromide (6-OHDA hydrobromide) 是神经递质多巴胺 (neurotransmitter dopamine) 拮抗剂，是一种广泛使用的神经毒素，可选择性地破坏多巴胺能神经元。 |
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Blum, D., Torch, S., Lambeng, N., et al.Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's diseaseProg. Neurobiol.65(2),135-172(2001)
Heuer, A., Smith, G.A., Lelos, M.J., et al.Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sitesBehav. Brain Res.228(1),30-43(2012)
Breese, G.R., and Traylor, T.D.Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neuronsJ. Pharmacol. Exp. Ther.174(3),413-420(1970)
Han, B.S., Noh, J.S., Gwag, B.J., et al.A distinct death mechanism is induced by 1-methyl-4-phenylpyridinium or by 6-hydroxydopamine in cultured rat cortical neurons: Degradation and dephosphorylation of tauNeurosci. Lett.341(2),99-102(2003)
Fujita, H., Ogino, T., Kobuchi, H., et al.Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathwayBrain Res.1113(1),10-23(2006)
He, Y., Lee, T., and Leong, S.K.6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigraBrain Res.858(1),163-166(2000)
