Cucurbitacin E
Cat. No.：YN280130
| 产品名称: | Cucurbitacin E |
| CAS No.: | 18444-66-1 |
| Chemical Name: | (9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione |
| Synonyms: | 葫芦素 E; α-Elaterin; α-Elaterine |
| 分子量: | 556.69 |
| 分子式: | C₃₂H₄₄O₈ |
| SMILES: | O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C(C(O)=C[C@@]4([H])[C@]3(C)C2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cucurbitacin E 是来自Cucumic melo L茎的一种天然化合物。Cucurbitacin E 显著抑制cyclin B1/CDC2复合物的活性。 |
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Arel-Dubeau, A.-M., Longpré, F., Bournival, J., et al.Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neuronsOxid. Med. Cell. Longev.,425496(2014)
Hsu, Y.-C., Huang, T.-Y., and Chen, M.-J.Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin ECell Death Dis.5(4),e1198(2014)
Kong, Y., Chen, J., Zhou, Z., et al.Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancerPloS One9(7),e103760(2014)
Huang, W.-W., Yang, Y.-S., Lin, M.-W., et al.Cucurbitacin E induces G2/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cellsEvid. Based Complement. Altnernat. Med.,952762(2012)
Greige-Gerges, H., Abou Khalil, R., Chahine, R., et al.Effect of cucurbitacins on bilirubin-albumin binding in human plasmaLife Sci.80(6),579-585(2007)
Sörensen, P.M., Iacob, R.E., Fritzsche, M., et al.The natural product cucurbitacin E inhibits depolymerization of actin filamentsACS Chem Biol.7(9),1502-1508(2012)
