Ponatinib hydrochloride
Cat. No.：YN280160
CAS No. ：1114544-31-8
| 产品名称: | Ponatinib hydrochloride |
| CAS No.: | 1114544-31-8 |
| Chemical Name: | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide, monohydrochloride |
| Synonyms: | AP24534 hydrochloride |
| 分子量: | 569.0203696 |
| 分子式: | C29H27F3N6O • HCl |
| SMILES: | O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)N([H])C4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ponatinib (AP24534) hydrochloride 是 ponatinib 的盐酸盐。Ponatinib 是一种有效的，具有口服活性的多靶点激酶抑制剂，抑制Abl，PDGFRα，VEGFR2，FGFR1和Src的IC50分别为 0.37 nM、1.1 nM、1.5 nM、2.2 nM 和 5.4 nM。 |
| IC50和靶点: | [{name:"VEGFR2:1.5 nM (IC50)"},{name: "FGFR1:2.2 nM (IC50)"},{name: "PDGFRα:1.1 nM (IC50)"},{name: "Abl:0.37 nM (IC50)"},{name: "LYN:0.24 nM (IC50)"},{name: "Src:5.4 nM (IC50)"}] |
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O'Hare, T., Shakespeare, W.C., Zhu, X., et al.AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistanceCancer Cell16(5),401-412(2009)
