IKK 16 hydrochloride
Cat. No.：YN280163
CAS No. ：1186195-62-9
| 产品名称: | IKK 16 hydrochloride |
| CAS No.: | 1186195-62-9 |
| Chemical Name: | [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone, monohydrochloride |
| Synonyms: | IKK 16;IKK-16 (hydrochloride) NEW;IKK-16 Hydrochloride |
| 分子量: | 520.1 |
| 分子式: | C28H29N5OS • HCl |
| SMILES: | O=C(N1CCC(N2CCCC2)CC1)C3=CC=C(C=C3)NC4=NC=CC(C5=CC(C=CC=C6)=C6S5)=N4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IKK16 hydrochloride 是一种选择性的 IκB 激酶 (IKK) 抑制剂，作用于IKK2，IKKcomplex和IKK1，IC50分别为 40 nM，70 nM 和 200 nM。IKK16 还抑制富亮氨酸重复激酶 2 (LRRK 2)，IC50为 50 nM。 |
| IC50和靶点: | [{name:"IKK2:40 nM (IC50)"},{name: "IKK1:200 nM (IC50)"},{name: "IKK:70 nM (IC50)"},{name: "LRRK2:50 nM (IC50)"}] |
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| Solvent & Solubility: |
Waelchli, R., Bollbuck, B., Bruns, C., et al.Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKKBioorg. Med. Chem. Lett.16(1),108-112(2006)
Coldewey, S.M., Rogazzo, M., Collino, M., et al.Inhibition of IᴋB kinase reduces the multiple organ dysfunction caused by sepsis in the mouseDis. Model. Mech.6(4),1031-1042(2013)
Thein, S., Pham, A., Bayer, K.U., et al.IKK regulates the deubiquitinase CYLD at the postsynaptic densityBiochem. Biophys. Res. Commun.450(1),550-554(2014)
Fallahi-Sichani, M., Moerke, N.J., Niepel, M., et al.Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosisMol. Syst. Biol.11(3),797(2015)
Sordi, R., Chiazza, F., Johnson, F.L., et al.Inhibition of IᴋB kinase attenuates the organ injury and dysfunction associated with hemorrhagic shockMol. Med.21(1),563-575(2015)
Tandon, M., Johnson, J., Li, Z., et al.New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cellsPLoS One8(9),e75601(2013)
Ansbro, M.R., Shukla, S., Ambudkar, S.V., et al.Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interferencePLoS One8(4),e60334(2013)
