MRT68921
Cat. No.：YN280164
| 产品名称: | MRT68921 |
| CAS No.: | 1190379-70-4 |
| Chemical Name: | N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide |
| Synonyms: | MRT67307; MRT-67307; MRT 67307; MRT67307 HCl. MRT67307 hydrochloride |
| 分子量: | 434.6 |
| 分子式: | C25H34N6O |
| SMILES: | CN(C1)CCC2=C1C=CC(NC3=NC=C(C4CC4)C(NCCCNC(C5CCC5)=O)=N3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRT68921 是ULK1和ULK2有效的抑制剂，IC50值分别为 2.9 nM 和 1.1 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Petherick, K.J., Conway, O.J.L., Mpamhanga, C., et al.Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagyJ. Biol. Chem.290(18),11376-11383(2015)
