SBP-7455
Cat. No.:YN280171
CAS No. :1884222-74-5
产品名称: | SBP-7455 |
CAS No.: | 1884222-74-5 |
Chemical Name: | N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)-2,4-pyrimidinediamine |
Synonyms: | |
分子量: | 354.3271496 |
分子式: | C16H17F3N4O2 |
SMILES: | FC(F)(C1=CN=C(NC2=CC=C(C(OC)=C2)OC)N=C1NC3CC3)F |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | SBP-7455 是一种有效的,高亲和力,具有口服活性的双重ULK1/ULK2自噬抑制剂,在 ADP-Glo 分析中的IC50分别为 13 nM 和 476 nM。SBP-7455 有效抑制ULK1/2酶活性,并可用于三阴性乳腺癌 (TNBC) 的研究。 |
IC50和靶点: | [{name:"ULK1:13 nM (IC50)"},{name: "ULK2:476 nM (IC50)"}] |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Ren, H., Bakas, N.A., Vamos, M., et al.Design, synthesis, and characterization of an orally active dual-specific ULK1/2 autophagy inhibitor that synergizes with the PARP inhibitor olaparib for the treatment of triple-negative breast cancerJ. Med. Chem.63(23),14609-14625(2020)