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Epothilone D

Cat. No.：189453-10-9

  • CAS No. ：189453-10-9

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    • 产品名称: Epothilone D
      CAS No.: 189453-10-9
      Chemical Name:
      Synonyms:KOS 862
      分子量:491.68
      分子式:C₂₇H₄₁NO₅S
      SMILES:O=C(O[C@@H](C/C=C(CCC[C@@H]([C@@H]([C@H](C1=O)C)O)C)/C)/C(C)=C/C2=CSC(C)=N2)C[C@@H](C1(C)C)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Bollag, D.M., McQueney, P.A., Zhu, J., et al.Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of actionCancer Res.55(11),2325-2333(1995)', 'Goodin, S., Kane, M.P., and Rubin, E.H.Epothilones: Mechanism of action and biologic activityJ. Clin. Oncol.22(10),2015-2025(2011)', 'Cheng, K.L., Bradley, T., and Budman, D.R.Novel microtubule-targeting agents - the epothilonesBiologics2(4),789-811(2008)', 'Cartelli, D., Casagrande, F., Busceti, C.L., et al.Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotectiveSci. Rep.3,(2013)', 'Brunden, K.R., Zhang, B., Carroll, J., et al.Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathyJ. Neurosci.30(41),13861-13866(2010)', "Lou, K., Yao, Y., Hoye, A.T., et al.Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathiesJ. Med. Chem.57(14),6116-6127(2014)
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