Gatifloxacin
Cat. No.：YN250122
CAS No. ：112811-59-3
| 产品名称: | Gatifloxacin |
| CAS No.: | 112811-59-3 |
| Chemical Name: | 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid |
| Synonyms: | 加替沙星; AM-1155; BMS-206584; PD135432 |
| 分子量: | 375.39 |
| 分子式: | C₁₉H₂₂FN₃O₄ |
| SMILES: | CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gatifloxacin (AM-1155) 是一种有效的氟喹诺酮类抗生素 (antibiotic)，具有广谱抗菌活性。Gatifloxacin 可抑制细菌 II 型拓扑异构酶 (type II topoisomerases) (IC50=13.8 μg/ml; 金黄色葡萄球菌拓扑异构酶 IV) 和大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)。Gatifloxacin 在动物模型中具有抗细菌性结膜炎作用。 |
| IC50和靶点: | |
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Takei, M., Fukuda, H., Yasue, T., et al.Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerasesAntimicrob. Agents Chemother.42(10),2678-2681(1998)
Park-Wyllie, L.Y., Juurlink, D.N., Kopp, A., et al.Outpatient gatifloxacin therapy and dysglycemia in older adultsN. Engl. J. Med.354(13),1352-1361(2006)
Cervantes, L.J., and Mah, F.S.Clinical use of gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitisClin. Ophthalmol.5(1),495-502(2011)
