6-Diazo-5-oxo-L-nor-Leucine
Cat. No.：YN250158
| 产品名称: | 6-Diazo-5-oxo-L-nor-Leucine |
| CAS No.: | 157-03-9 |
| Chemical Name: | 6-diazo-5-oxo-L-norleucine |
| Synonyms: | L-6-Diazo-5-oxonorleucine; DON |
| 分子量: | 171.15 |
| 分子式: | C₆H₉N₃O₃ |
| SMILES: | N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂，其Ki值为 6 μM。L-6-Diazo-5-oxonorleucine 具有镇痛、抗菌、抗病毒和抗癌作用。L-6-Diazo-5-oxonorleucine 在体外表现出遗传毒性。L-6-Diazo-5-oxonorleucine 能降低肿瘤细胞的自我更新能力和转移能力 。 |
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Willis, R.C., and Seegmiller, J.E.The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblastJ. Cell Physiol.93,375-382(1977)
Thangavelu, K., Chong, Q.Y., Low, B.C., et al.Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA)Sci. Rep.4,1-7(2014)
Thomas, A.G., Rojas, C., Tanega, C., et al.Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitorsBiochem. Biophys. Res. Commun.438(2),243-248(2013)
Botman, D., Tigchelaar, W., and Van Noorden, C.J.F.Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)J. Histochem. Cytochem.62(11),813-826(2014)
Greene, R.M., and Kochhar, D.M.Limb development in mouse embryos: Protection against teratogenic effects of 6-diazo-5-ox-ʟ-norleucine (DON) in vivo and in vitroJ. Embryol. Exp. Morphol.33(2),355-370(1975)
