Piericidin A
Cat. No.：YN250241
CAS No. ：2738-64-9
| 产品名称: | Piericidin A |
| CAS No.: | 2738-64-9 |
| Chemical Name: | 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol |
| Synonyms: | AR-054 |
| 分子量: | 415.57 |
| 分子式: | C₂₅H₃₇NO₄ |
| SMILES: | COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶 (复合物 I;complex I) 抑制剂。Piericidin A 是一种有效的神经毒素，通过其对 NADH-泛醌还原酶 (NADH-ubiquinone reductase) 的作用破坏电子传输系统，从而抑制线粒体呼吸。Piericidin A 还是一种潜在的群体感应抑制剂，可抑制胡萝卜欧文氏菌亚种atroseptica(Eca) 的毒力基因的表达。Piericidin A 是一种 ADC 细胞毒素，具有抗菌，抗癌 |
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Hatefi, Y.Flavoproteins of the electron transport system and the site of action of amytal, rotenone, and piericidin AProc. Natl. Acad. Sci. USA60(2),733-740(1968)
Melo, A.M.P., Bandeiras, T.M., and Teixeira, M.New insights into type II NAD(P)H:quinone oxidoreductasesMicrobiol. Mol. Biol. Rev.68(4),603-616(2004)
Takahashi, N., Suzuki, A., and Tamura, S.Structure of piericidin AJ. Am. Chem. Soc.87(9),2066-2068(1965)
Horgan, D.J., and Casida, J.E.Specific binding of [14C] piericidin A in the reduced nicotinamide--adenine dinucleotide dehydrogenase segment of the mitochondrial respiratory chainBiochem. J.108(1),153-154(1968)
Fato, R., Bergamini, C., Bortolus, M., et al.Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen speciesBiochim. Biophys. Acta1787(5),384-392(2009)
Ikezawa, N., Ifuku, K., Endo, T., et al.Inhibition of photosystem II of spinach by the respiration inhibitors piericidin A and thenoyltrifluoroacetoneBiosci. Biotechnol. Biochem.66(9),1925-1929(2002)
Hwang, J.H., Kim, J.Y., Cha, M.R., et al.Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulatorJ. Cell Physiol.215(1),243-250(2008)
