Ilimaquinone
Cat. No.：YN250278
CAS No. ：71678-03-0
| 产品名称: | Ilimaquinone |
| CAS No.: | 71678-03-0 |
| Chemical Name: | 3-[[(1R,2S,4aS,8aS)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | |
| 分子量: | 358.47 |
| 分子式: | C₂₂H₃₀O₄ |
| SMILES: | C=C1[C@]2(CC[C@@H]([C@](C)([C@@]2(CCC1)[H])CC3=C(C(C=C(C3=O)OC)=O)O)C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ilimaquinone 是一种海洋海绵状代谢产物，通过 GADD153 介导的信号通路发挥抗肿瘤活性。Ilimaquinone 可以诱导高尔基体的囊泡化。Ilimaquinone 具有抗病毒，抗菌和抗炎活性。 |
| IC50和靶点: | |
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Radeke, H.S., Digits, C.A., Casaubon, R.L., et al.Interactions of (-)-ilimaquinone with methylation enzymes: Implications for vesicular-mediated secretionChem. Biol.6(9),639-647(1999)
Takizawa, P.A., Yucel, J.K., Veit, B., et al.Complete vesiculation of golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinoneCell73(6),1079-1090(1993)
Cruciani, V., Leithe, E., and Mikalsen, S.O.Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transportExp. Cell Res.287(1),130-142(2003)
Kim, B.G., Chun, T.G., Lee, H.Y., et al.A new structural class of S-adenosylhomocysteine hydrolase inhibitorsBioorg. Med. Chem.17(18),6707-6714(2009)
Cao, S., Gao, Z., Thomas, S.J., et al.Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase βJ. Nat. Prod.67(10),1716-1718(2004)
Du, L., Zhou, Y.D., and Nagle, D.G.Inducers of hypoxic response: Marine sesquiterpene quinones activate HIF-1J. Nat. Prod.76(6),1175-1181(2013)
