Ansatrienin B
Cat. No.：YN250323
| 产品名称: | Ansatrienin B |
| CAS No.: | 82189-04-6 |
| Chemical Name: | N-(cyclohexylcarbonyl)-D-alanine, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester |
| Synonyms: | Mycotrienin II |
| 分子量: | 638.79 |
| 分子式: | C₃₆H₅₀N₂O₈ |
| SMILES: | O=C(C1CCCCC1)N[C@@H](C(O[C@@H](C/C=C/C=C/C=C/[C@@H](C2)OC)[C@@H]([C@H](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性，但对细菌无活性。Ansatrienin B 具有抗肿瘤活性，可作为 ADC 毒素分子。 |
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Damberg, M., Russ, P., and Zeeck, A.Die konstitution der fungistatischen ansamycin-antibiotica ansatrienin A und BTetrahedron Lett.23(1),59-62(1982)
Sugita, M., Natori, Y., Sasaki, T., et al.Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and IIJ. Antibiot. (Tokyo)35(11),1460-1466(1982)
Feuerbach, D., Waelchli, R., Fehr, T., et al.Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorptionJ. Biol. Chem.270(43),25949-25955(1995)
Yamada, Y., Tashiro, E., Taketani, S., et al.Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokinesJ. Antibiot. (Tokyo)64(5),361-366(2011)
Kuwano, M., Ikezaki, K., Mamizuka, K., et al.Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienolsGan.74(5),759-766(1983)
