Micrococcin P1
Cat. No.：YN250368
| 产品名称: | Micrococcin P1 |
| CAS No.: | 67401-56-3 |
| Chemical Name: | 2’-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrat |
| Synonyms: | 微球菌素 P1 |
| 分子量: | 1144.37 |
| 分子式: | C₄₈H₄₉N₁₃O₉S₆ |
| SMILES: | C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Micrococcin P1 是一种大环肽抗生素，是一种有效的丙型肝炎病毒 (HCV) 抑制剂，EC50范围为 0.1-0.5 μM。Micrococcin P1 对革兰氏阳性细菌菌株具有体外抗菌活性，对金黄色葡萄球菌 1974149 菌株，粪肠球菌 1674621 菌株和化脓性链球菌 1744264 菌株的 MIC 值分别为 2 μg/ mL，1 μg/ mL 和 1 μg/ mL。Micrococcin P1 还是疟疾寄生虫恶性疟原虫的有效抑制剂。 |
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Carnio, M.C., Hötzel, A., Rudolf, M., et al.The macrocyclic peptide antibiotic micrococcin P(1) is secreted by the food-borne bacterium Staphylococcus equorum WS 2733 and inhibits Listeria monocytogenes on soft cheeseAppl. Environ. Microbiol.66(6),2378-2384(2000)
Mikolajka, A., Liu, H., Chen, Y., et al.Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPasesChem. Biol.18(5),589-600(2011)
