Phleomycin
Cat. No.：YN250391
CAS No. ：11006-33-0
| 产品名称: | Phleomycin |
| CAS No.: | 11006-33-0 |
| Chemical Name: | (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-(2-(6-amino-2-(3-amino-1-((2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-((5-((1-((2-(4-((4-guanidinobutyl)carbamoyl)-4',5'-dihydro-[2,4'-bithiazol]-2'-yl)ethyl)amino)-3-hydroxy-1-o |
| Synonyms: | |
| 分子量: | 暂无 |
| 分子式: | 暂无 |
| SMILES: | [Phleomycin] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phleomycin 是在链霉菌中发现的，具有抗肿瘤活性的糖肽类抗生素 (antibiotic)，可引起 DNA 断裂。与博来霉素 (Bleomycin, HY-17565A) 类似，它与 DNA 结合并插入，破坏双螺旋结构的完整性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Moore, C.W.Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeastCancer Res.48(23),6837-6843(1988)
Hecht, S.M.Bleomycin: New perspectives on the mechanism of actionJ. Nat. Prod.63(1),158-168(2000)
Kajiwara, K., Kim, U.H., and Mueller, G.C.Phleomycin, an inhibitor of replication of HeLa cellsCancer Res.26(2),233-236(1966)
Allen, T.E., Brown, D.J., Cowden, W.B., et al.Amplification of the antitumor activity of phleomycins in rats and mice by heterocyclic analogues of purinesJ. Antibiot. (Tokyo)37(4),376-383(1984)
Gatignol, A., Baron, M., and Tiraby, G.Phleomycin resistance encoded by the ble gene from transposon Tn 5 as a dominant selectable marker in Saccharomyces cerevisiaeMol. Gen. Genet.207(2-3),342-348(1987)
Wenzel, T.J., Migliazza, A., Steensma, H.Y., et al.Efficient selection of phleomycin-resistant Saccharomyces cerevisiae transformantsYeast8(8),667-668(1992)
Vickers, C.E., Bydder, S.F., and Nielsen, L.K.Dual gene expression cassette vectors with antibiotic selection markers for engineering in Saccharomyces cerevisiaeMicrob. Cell Fact.12,96(2013)
