Tizoxanide
Cat. No.：YN250397
CAS No. ：173903-47-4
| 产品名称: | Tizoxanide |
| CAS No.: | 173903-47-4 |
| Chemical Name: | 2-hydroxy-N-(5-nitro-2-thiazolyl)-benzamide |
| Synonyms: | 替唑尼特; TIZ |
| 分子量: | 265.25 |
| 分子式: | C₁₀H₇N₃O₄S |
| SMILES: | O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tizoxanide 是 Nitazoxanide 活性代谢物，Nitazoxanide可抗细菌和多种病毒复制。Tizoxanide 具有抗HIV-1的活性。 |
| IC50和靶点: | |
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de Carvalho, L.P.S., Lin, G., Jiang, X., et al.Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistanceJ. Med. Chem.52(19),5789-5792(2009)
Korba, B.E., Montero, A.B., Farrar, K., et al.Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replicationAntiviral Res.77(1),56-63(2008)
Chan-Bacab, M.J., Hernández-Núñez, E., and Navarrete-Vázquez, G.Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitroJ. Antimicrob. Chemother.63(6),1292-1293(2009)
Rossignol, J.F., La Frazia, S., Chiappa, L., et al.Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational levelJ. Biol. Chem.284(43),29798-29808(2009)
