Macozinone
Cat. No.：YN250422
CAS No. ：1377239-83-2
| 产品名称: | Macozinone |
| CAS No.: | 1377239-83-2 |
| Chemical Name: | 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| Synonyms: | PBTZ169 |
| 分子量: | 456.48 |
| 分子式: | C₂₀H₂₃F₃N₄O₃S |
| SMILES: | O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Macozinone (PBTZ169) 是一种杀菌型苯并噻嗪酮，也是有效的DprE1抑制剂。Macozinone 可通过与活性位点 Cys387 残基形成共价键来抑制必需的黄素蛋白 DprE1。Macozinone 有抗结核作用。 |
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Peng, C.T., Gao, C., Wang, N.Y., et al.Synthesis and antitubercular evaluation of 4-carbonyl piperazine substituted 1,3-benzothiazin-4-one derivativesBioorg. Med. Chem. Lett.25(7),1373-1376(2015)
Makarov, V., Lechartier, B., Zhang, M., et al.Towards a new combination therapy for tuberculosis with next generation benzothiazinonesEMBO Mol. Med.6(3),372-383(2014)
