Sapienic acid
Cat. No.:YN250438
产品名称: | Sapienic acid |
CAS No.: | 17004-51-2 |
Chemical Name: | 6Z-hexadecenoic acid |
Synonyms: | |
分子量: | 254.41 |
分子式: | C₁₆H₃₀O₂ |
SMILES: | CCCCCCCCC/C=C\CCCCC(O)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Sapienic acid 是一种常见于皮肤和粘膜中的脂肪酸,对皮肤和口腔中发现的革兰氏阳性和革兰氏阴性细菌具有可变的抗菌活性。Sapienic acid 对血链球菌,微生物链球菌和核纤梭菌具有活性,其 MBC 值分别为 31.3 μg/mL,375.0 μg/mL 和 93.8 μg/mL。 |
IC50和靶点: | |
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Takigawa, H., Nakagawa, H., Kuzukawa, M., et al.Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureusDermatology211(3),240-248(2005)
Li, W.-H., Zhang, Q., Flach, C.R., et al.In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesionsArch. Dermatol. Res.309(7),529-540(2017)
Cartron, M.L., England, S.R., Chiriac, A.I., et al.Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureusAntimicrob. Agents Chemother.58(7),3599-3609(2014)