Pirarubicin
Cat. No.：YN250556
CAS No. ：72496-41-4
规格
价格(RMB)
库存
| 产品名称: | Pirarubicin |
| CAS No.: | 72496-41-4 |
| Chemical Name: | (8S,10S)-10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione |
| Synonyms: | 吡柔比星; THP |
| 分子量: | 627.64 |
| 分子式: | C₃₂H₃₇NO₁₂ |
| SMILES: | O=C1C2=C(C=CC=C2OC)C(C3=C(O)C4=C([C@@H](O[C@@]5([H])C[C@H](N)[C@H](O[C@@]6([H])OCCCC6)[C@H](C)O5)C[C@@](C(CO)=O)(O)C4)C(O)=C31)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pirarubicin (THP) 是一种蒽环类抗生素，为拓扑异构酶 II (topoisomerase II) 的抑制剂，可用于各种癌症尤其是实体瘤的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Monneret, C.Recent developments in the field of antitumour anthracyclinesEur. J. Med. Chem.36(6),483-493(2001)
Tsuchiya, K.S., Ishii, T., Ikeno, S., et al.Inhibition of anchorage-independent growth of tumor cells by IT-62-B, a new anthracyclineJ. Antibiot. (Tokyo)50(10),853-859(1997)
Huang, H., Chen, T., Zhou, Y., et al.RIPK1 inhibition enhances pirarubicin cytotoxic efficacy through AKT-P21-dependent pathway in hepatocellular carcinomaInt. J. Med. Sci.15(14),1648-1657(2018)
Sugiyama, T., Sadzuka, Y., Nagasawa, K., et al.Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicinJpn. J. Cancer Res.90(7),775-780(1999)
