Zoliflodacin

Cat. No.：YN250777

CAS No. ：1620458-09-4

产品名称:	Zoliflodacin
CAS No.:	1620458-09-4
Chemical Name:	(2R,4S,4aS)-11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]-Spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione
Synonyms:	ETX0914; AZD0914
分子量:	487.44
分子式:	C₂₂H₂₂FN₅O₇
SMILES:	O=C(NC(C12[C@]([C@H](C)O[C@H](C)C3)([H])N3C4=C(C=C5C(ON=C5N6C(OC[C@@H]6C)=O)=C4F)C2)=O)NC1=O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	Zoliflodacin (ETX0914;AZD0914) 是一种新型的螺旋嘧啶三酮，细菌DNA促旋酶/拓扑异构酶抑制剂。Zoliflodacin 对革兰氏阳性和阴性生物具有有效的体外抗菌活性，对金黄色葡萄球菌的b>MIC90值为0.25 μg/mL。
IC50和靶点:
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In Vivo:
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Jacobsson, S., Golparian, D., Alm, R.A., et al.High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrheaAntimicrob. Agents Chemother.58(9),5585-5588(2014)
Biedenbach, D.J., Huband, M.D., Hackel, M., et al.In vitro activity of AZD0914, a novel bacterial DNA gyrase/topoisomerase IV inhibitor, against clinically relevant Gram-positive and fastidious Gram-negative pathogensAntimicrob. Agents Chemother.59(10),6053-6063(2015)
Kohlhoff, S.A., Huband, M.D., and Hammerschlag, M.R.In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniaeAntimicrob. Agents Chemother.58(12),7595-7596(2014)