Floxuridine
Cat. No.：YN250905
| 产品名称: | Floxuridine |
| CAS No.: | 50-91-9 |
| Chemical Name: | 2'-deoxy-5-fluoro-uridine |
| Synonyms: | 氟尿苷; 5-Fluorouracil 2'-deoxyriboside |
| 分子量: | 246.19 |
| 分子式: | C₉H₁₁FN₂O₅ |
| SMILES: | OC[C@@H]1[C@H](C[C@H](N2C(NC(C(F)=C2)=O)=O)O1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Floxuridine (5-Fluorouracil 2'-deoxyriboside) 是一种嘧啶类似物，被也是一种抗肿瘤代谢物 (oncology antimetabolites)。Floxuridine 通过激活 ATM 和 ATR 检查点信号通路，在体外抑制Poly(ADP-Ribose) polymerase并诱导 DNA 损伤。Floxuridine 是一种非常有效的金黄色葡萄球菌感染抑制剂并且可以诱导细胞凋亡 (apoptosis)。Floxuridine 具有抗HSV和CMV病毒的作用。 |
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Tzioumaki, N., Manta, S., Tsoukala, E., et al.Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: Novel 5-fluorouracil analogs that target thymidylate synthaseEur. J. Med. Chem.46(4),993-1005(2011)
Yoshioka, A., Tanaka, S., Hiraoka, O., et al.Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell deathJ. Biol. Chem.262(17),8235-8241(1987)
Bollag, W., and Hartmann, H.R.Tumor inhibitory effects of a new fluorouracil derivative: 5'-Deoxy-5-fluorouridineEur. J. Cancer16(4),427-432(1980)
