Omeprazole
Cat. No.：YN250911
| 产品名称: | Omeprazole |
| CAS No.: | 73590-58-6 |
| Chemical Name: | 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole |
| Synonyms: | 奥美拉挫; H 16868 |
| 分子量: | 345.42 |
| 分子式: | C₁₇H₁₉N₃O₃S |
| SMILES: | O=S(C1=NC2=CC=C(OC)C=C2N1)CC3=NC=C(C)C(OC)=C3C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Omeprazole (H 16868) 是一种质子泵 (proton pump) 抑制剂 (PPI)，有潜力用于胃肠道疾病的研究。Omeprazole 竞争性抑制CYP2C19活性，Ki为 2 到 6 μM。Omeprazole 还抑制革兰氏阳性菌和革兰氏阴性菌生长。Omeprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂)。 |
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Smolka, A.J., Goldenring, J.R., Gupta, S., et al.Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000BMC Gastroenterol.4(4),(2004)
Lind, T., Rydberg, L., Kylebäck, A., et al.Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux diseaseAliment. Pharmacol. Ther.14(7),861-867(2000)
Suzuki, M., Mori, M., Miura, S., et al.Omeprazole attenuates oxygen-derived free radical production from human neutrophilsFree Radic. Biol. Med.21(5),727-731(1996)
Iwahi, T., Satoh, H., Nakao, M., et al.Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pyloriAntimicrob. Agents Chemother.35(3),490-496(1991)
Larsson, H., Carlsson, E., Junggren, U., et al.Inhibition of gastric acid secretion by omeprazole in the dog and ratGastroenterology85(4),900-907(1983)
