Tigecycline
Cat. No.：YN250912
CAS No. ：220620-09-7
| 产品名称: | Tigecycline |
| CAS No.: | 220620-09-7 |
| Chemical Name: | 4S,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4S,4aS,5,5aR,6,11,12a-octahydro-3,10,12,12aS-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide |
| Synonyms: | 替加环素; GAR-936 |
| 分子量: | 585.65 |
| 分子式: | C₂₉H₃₉N₅O₈ |
| SMILES: | O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tigecycline (GAR-936) 是一种广谱的甘氨酰环素抗生素。Tigecycline 对E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/ mL。对Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。 |
| IC50和靶点: | |
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Greer, N.D.Tigecycline (Tygacil): The first in the glycylcycline class of antibioticsProc. (Bayl. Univ. Med. Cent.)19(2),155-161(2006)
Milatovic, D., Schmitz, F.J., Verhoef, J., et al.Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolatesAntimicrob. Agents Chemother.47(1),400-404(2003)
Theriot, C.M., Schumacher, C.A., Bassis, C.M., et al.Effects of tigecycline and vancomycin administration on established Clostridium difficile infectionAntimicrob. Agents Chemother.59(3),1596-1604(2015)
